RNA Details
Disease Name
pulmonary fibrosis
Tissue
lung
RNA Symbol
Aldh2
RNA ID
RNA Type
mRNA
Alteration Pattern
dysregulation
Species
mus musculus
Detection Methods
NA
Target
NA
Pathway
NA
PubMed ID
Title
Spontaneous Lung Fibrosis Resolution Reveals Novel Antifibrotic Regulators
Year
2021
Function
"Two genes from these analyses that were decreased in expression at Day 14 and reversed at Day 30, Aldh2 and Nr3c1, were selected for further analysis. Enhancement of endogenous expression of either gene by CRISPR activation in cultured human idiopathic pulmonary fibrosis fibroblasts was sufficient to reduce profibrotic gene expression, fibronectin deposition, and collagen gel compaction, consistent with roles for these genes in fibroblast deactivation."